Science

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Hetero-octameric MspA in the identificationof nucleoside monophosphates 

and their epigenetic modifications





Submission History


Rejected by: Nature, Science, Nature Biotechnology, Nature Methods, Nature Chemistry, Nature Chemical Biology, Nature Genetics (count: 7)


Accepted by: Nature Nanotechnology (Cover Story)Nature Nanotechnology 2022, 17 (9), 976-983.


Handling Editor: Dr. Wenjie Sun, efficient, responsible and is sincerely acknowledged

Submission to Acceptance: 121 days.


Media report:人民日报,Nature Nanotechnology, Nature Methods

Academic achievement: The first nanopore that can simultaneously resolve all major RNA epigenetic modifications.













Hetero-octameric MspA in the identification of all 20 proteinogenic amino acids 

and their post translational modifications







Submission History

Rejected by: Nature, Science, Nature Nanotechnology (count: 3)


Accepted by: Nature Methods;(Nature Methods 2024, 21 (1), 92-101.)

Handling Editor: Dr. Arunima Singh, extremely warm hearted, inspiring and is sincerely acknowledged

Submission to Acceptance: 207 days




Media Report and research highlight: 人民日报,Nature Methods2023年中国生物信息学十大进展。

Academic achievement: The first nanopore that can simultaneously resolve all 20 proteinogenic amino acids and their post translational modifications (PTM).














Hetero-octameric MspA in the identification of all major monosaccharides





Submission History

Rejected by: Nature, Science, Nature Nanotechnology, Nature Chemistry, Nature Biotechnology, Nature Chemical Biology, Nature MethodsJACS, Nature Communications, Science Advances, ACS Central Science  (count: 11)

Peer Reviewed but rejected by: PNAS (count: 1)




Appealed and Accepted by: Angewandte Chemie International Edition(Angewandte Chemie International Edition 202261(33), e202203769)

Handling Editor: Dr. Eric Castro, extremely efficient, hard working and fair editor and is sincerely acknowledged

Submission to Acceptance: 87 days, VIP paper

Academic achievement: The first nanopore that can simultaneously resolve ALL MAJOR MONOSACCHARIDES.













Programmable Nano-reactor for stochastic sensing (PNRSS)





Submission History

Rejected by: Nature, Science, Nature Nanotechnology, Nature Chemistry, Nature Biotechnology, Nature Chemical Biology, Nature Methods (count: 7)

Peer Reviewed but rejected by: Nature Nanotechnology (count: 1)

Accepted by: Nature Communications(Nature Communications 2021, 12 (1), 5811.)



Handling Editor: Dr. Robert Guilliatt, our life saver, definitely sincerely acknowledged

Submission to Acceptance: 53 days

Academic achievement: The first PROGRAMMABLE nanopore reactor.













Nanopore analysis of fruits





Submission History

Rejected by: Nature Chemistry, Journal of the American Chemical Society (count: 2)


Peer Reviewed but rejected by: Nature Food (count: 1)




Accepted without peer review by: Nature Communications(Nature Communications 2024, 15 (1), 1969.)

Handling Editor: Dr. Majda Bratovic, efficient and tolerant, definitely sincerely acknowledged

Submission to Acceptance: 35 days

Academic achievement: The first demonstration of nanopore analysis of fruits. A representative demo of nanopore REAL WORLD analysis.




蛋白质3D动态图

α-HL 

MspA 

ClyA 

phi29 DNAP 

 

 

不同生物纳米孔的晶体结构


图注:

A.   α-hemolysin (α-HL)    B.    Mycobacterium smegmatis porin A (MspA)    C.    Ferric hydroxamate uptake A (FhuA)

   D.   Outer membrane protein G (OmpG)             E.    Aerolysin (AeL)             F.     Outer membrane protein F (OmpF)

    G.    Escherichia coli curli production assembly/ transport component CsgG (CsgG)     H.    Fragaceatoxin C (FraC)   

     I.     Ф29 portal protein (Ф29p)         J.     Cytolysin A (ClyA)



高通量光学纳米孔分析技术微液滴纳米孔阵列用于平行化单分子分析

Address: Prof. Shuo Huang Room A220/A221 School of Chemistry & Chemical Engineering

Nanjing University 163 Xianlin Ave, Nanjing, China 210023

Email: shuo.huang@nju.edu.cn

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