【1】Wang, K. #; Zhang, S. #; Zhou, X. #; Yang, X.; Li, X.; Wang, Y.; Fan, P.; Xiao, Y.; Sun, W.; Zhang, P.; Li, W.; Huang, S. *; Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore.

Nature Methods

,2024,21 (1), 92-101.

【2】Wang, Y.#; Zhang, S. #; Jia, W. #; Fan, P.; Wang, L.; Li, X.; Chen, J.; Cao, Z.; Du, X.; Liu, Y.; Wang, K.; Hu, C.; Zhang, J.; Hu, J., Zhang, P.; Chen, H.-Y.; Huang, S.* Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore.

Nature Nanotechnology

,2022,17 (9), 976-983.（2023年江苏省自然科学百篇优秀学术成果论文）

【3】Liu, Y.#; Zhang, S.#; Wang, Y.; Wang, L.; Cao, Z.; Sun, W.; Fan, P.; Zhang, P.; Chen, H.-Y.; Huang, S.*, Nanopore identification of alditol epimers and their application in rapid analysis of alditol-containing drinks and healthcare products.

Journal of the American Chemical Society

,2022,144(30), 13717–13728

【4】Liu, Y.; Wang, K.; Wang, Y.; Yan, S.; Du, X.; Zhang, P.; Chen, H.-Y.; Huang, S.* Machine Learning assisted simultaneous structural profiling of differently charged proteins in a Mycobacterium smegmatis porin A (MspA) electroosmotic trap.

Journal of the American Chemical Society

,2022,144(2), 757–768

【5】 Wang, Y. Q.; Wang, Y.; Du, X. Y.; Yan, S. H.; Zhang, P. K.; Chen, H. Y.*; Huang, S.*, Electrode-free nanopore sensing by DiffusiOptoPhysiology.

Science Advances

,2019,5 (9), eaar3309

【6】Zhang, S.#; Cao, Z.#; Fan, P.#; Sun, W.; Xiao, Y.; Zhang, P.; Wang, Y. *; Huang, S.*, Discrimination of Disaccharide Isomers of Different Glycosidic Linkages Using a Modified MspA Nanopore.

Angewandte Chemie International Edition

,2024, 63 (8), e202316766.

【7】Yang, J. #; Wang, K. #; Zhang, S.; Zheng, X.; Cui, T.; Yang, X.; Liu, Y.; Lu, D.; Wang, Y.; Tian, X.; Zhang, P.; Huang, S. *; Xie, R. *, Site-Specific Introduction of Bioorthogonal Handles to Nanopores by Genetic Code Expansion.

Angewandte Chemie International Edition

,2023, 62(21)e202216115

【8】Zhang, S.#; Cao, Z.#; Fan, P.#; Wang, Y.; Jia, W.; Wang, L.; Wang, K.; Liu, Y.; Du, X.; Hu, C.; Zhang, P.; Chen, H.-Y.; Huang, S.* A Nanopore-Based Saccharide Sensor.

Angewandte Chemie International Edition

,2022,61(33) :e202203769

【9】Yan, S.#; Wang, L.#; Wang, Y.; Cao, Z.; Zhang, S.; Du, X.; Fan, P.; Zhang, P.; Chen, H.-Y.; Huang, S.* , Non-binary Encoded Nucleic Acid Barcodes Directly Readable by a Nanopore.

Angewandte Chemie International Edition

,2022,61 (20), e202116482.

【10】 Liu, Y.; Pan, T.; Wang, K.; Wang, Y.; Yan, S.; Wang, L.; Zhang, S.; Du, X.; Jia, W.; Zhang, P.; Chen, H.-Y.; Huang, S.*Allosteric Switching of Calmodulin in a Mycobacterium smegmatis porin A (MspA) Nanopore-Trap.

Angewandte Chemie International Edition

,2021, 60(44), 23863–23870

【11】 Wang, Y.#; Patil, K. M.#; Yan, S. H.; Zhang, P. K.; Guo, W. M.; Wang, Y. Q.; Chen, H. Y.; Gillingham, D.*; Huang, S.*, Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O6-Carboxymethyl Guanine and Reveals Its Behavior in Replicatio

Angewandte Chemie International Edition

,2019,58 (25), 8432-8436.

【12】Fan, P.#; Cao, Z.#; Zhang, S.#; Wang, Y.; Xiao, Y.; Jia, W.; Zhang, P.; Huang, S.*, Nanopore analysis of cis-diols in fruits.

Nature Communications

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【13】Fan, P.#; Zhang, S.#; Wang, Y.; Li, T.; Zhang, H.; Zhang, P.; Huang, S.*, Nanopore analysis of salvianolic acids in herbal medicines.

Nature Communications

,2024,15 (1), 1970.

【14】Jia, W.; Hu, C.; Wang, Y.; Gu, Y.; Qian, G.; Du, X.; Wang, L.; Liu, Y.; Cao, J.; Zhang, S.; Yan, S.; Zhang, P.; Ma, J.; Chen, H.-Y.; Huang, S.*, Programmable Nano-Reactors for Stochastic Sensing.

Nature Communications

,2021,12(1), 5811

【15】 Cao, J.; Jia, W. D.; Zhang, J. Y.; Xu, X. M.; Yan, S. H.; Wang, Y. Q.; Zhang, P. K.; Chen, H.-Y.; Huang, S.*, Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore.

Nature Communications

,2019,10 (1), 5668

【16】 Wang, Y. Q.#; Guan, X. Y.#; Zhang, S. Y.; Liu , Y.; Wang, S.; Fan , P. P.; Du, X. Y.; Yan , S.; Zhang , P. K.; Chen, H.-Y.; Li , W. F.*; Zhang, D. Q.*; Huang, S.*,Structural-profiling of low molecular weight RNAs by nanopore trapping/translocation using Mycobacterium smegmatis porin A.

Nature Communications

,2021,12(1), 3368

【17】Du, X.#; Zhang, S.#; Wang, L.; Wang, Y.; Fan, P.;Jia, W.; Zhang, P.; Huang, S.* Single Molecule Interconversion between Chiral Configurations of Boronate Esters Observed in a Nanoreactor.

ACS Nano

,2023,17(3), 2881–2892

【18】Wang, Y.#; Fan, P.#; Zhang, S.; Wang, L.; Li, X.; Jia, W.;Liu, Y.; Wang, K.; Du, X.; Zhang, P.; Huang, S.* Discrimination of ribonucleoside mono-, di-, and triphosphates using an engineered nanopore.

ACS Nano

,2022,16(12), 21356–21365

【19】Jia, W.; Hu, C.; Wang, Y.; Liu, Y.; Wang, L.; Zhang, S.; Zhu, Q.; Gu, Y.; Zhang, P.; Ma, J.; Chen, H.-Y.; Huang, S.* Identification of Single-Molecule Catecholamine Enantiomers Using a Programmable Nanopore

ACS Nano

,2022,16(4): 6615-6624.

【20】Ouyang, Y.#; Wang, K.#; Jia, W.; Zhang, P.; Huang, S.* Simultaneous Identification of Vitamins B1, B3, B5, and B6 by an Engineered Nanopore.

Nano Letters

,2024,24(38), 11944–11953​

【21】Wang, K. #; Yang, X. #; Xiao, Y.; Cao, Z.; Zhang, S.; Zhang, P.; Huang, S.*, Simultaneous Identification of Major Thyroid Hormones by a Nickel Immobilized Biological Nanopore.

Nano Letters

,2024, 24(1), 305–311

【22】Jia, W.; Ouyang, Y.; Zhang, S.; Du, X.; Zhang, P.; Huang, S., Nanopore Signatures of Nucleoside Drugs.

Nano Letters

,2023,23(20), 9437–9444

【23】Wang, K. #; Yang, X. #; Zhang, S.; Zhang, P.; Huang, S.*, Nanopore Discrimination of Nucleotide Sugars.

Nano Letters

,2023,23(18), 8620–8627

【24】Zhang, J. #; Wang, Y. #; Wang, Y.; Zhang, P.; Chen, H.-Y.; Huang, S.*, Discrimination between different DNA lesions by monitoring single molecule polymerase stalling kinetics during nanopore sequencing.

Nano Letters

,2022,22(13), 5561–5569

【25】 Yan, S. H.; Zhang, J. Y.; Wang, Y.; Guo, W.M.; Zhang, S. Y.; Liu. Y.; Cao, J.; Wang, Y. Q.; Wang, L. Y.; Ma, F. B.; Zhang, P. K.; Chen, H. Y.; Huang, S.*，Single Molecule Ratcheting Motion of Peptides in a Mycobacterium smegmatis Porin A (MspA) Nanopore.

Nano Letters

,2021,21(15), 6703–6710

【26】 Huang, S.#; Romero-Ruiz, M.#; Castell, O. K.; Bayley, H.; Wallace, M. I.*, High-throughput optical sensing of nucleic acids in a nanopore array.

Nature Nanotechnology

,2015,10(11), 986-991.

【27】 Huang, S.; He, J.; Chang, S.; Zhang, P. M.; Liang, F.; Li, S. Q.; Tuchband, M.; Fuhrmann, A.; Ros, R.; Lindsay, S.*, Identifying single bases in a DNA oligomer with electron tunnelling.

Nature Nanotechnology

,2010,5 (12), 868-873