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Cryo-SEM of in situ assembling nanoparticles on a cell surface


We have demonstrated that a small molecule probe, can be triggered by ALP expressed on HeLa cell surfacen, to form spherical nanoparticles anchored on the cell surface via a in situ self-assembly process. The in situ formed nanoparticles were clearly observed using cryo-SEM and TEM. More stroy, please read the paper entitled "Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly" that has been published in JACS on June 7.

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