Research in Ye Lab is aiming to integrate Analytical Chemistry, Chemical Biology and Nanotechnology to build activatable multimodality molecular probes for non-invasive imaging of biomolecules and pathological processes in vivo. Guided by the imaging, we are aiming to provide tool for better diagnosis and treatment of diseases (e.g, cancers, Inflammation). We are now working on three major projects:
(1) Activatable Multimodal Probes
Activatable probes, where the imaging signal can be switched "on" from an "off" state in response to a specific molecular target, allow for signal amplification and/or specific retention at the site of interaction to produce enhanced imaging contrast. Activatable probes are generally characterized by improved sensitivity and specificity,which are advantageous for non-invasive and real-time detection of biomolecules in vivo by molecular imaging. The major project in our lab is aiming to develop activatable multimodal imaging probes with combined sensitivity and spatial resolution for in vivo applications.(Nat. Chem. 2014, 6, 519; Sci. Bull. 2016, 61, 1672 (Reviews))
(2) Multimodality Imaging in vivo
Multimodal molecular imaging is now emerging as a powerful tool for both biomedical research and clinical diagnosis. By utiltzing the strengths of combinatorial modalities, it provides a hybrid imaging platform with superior results in term of sensitivity, specificity, temporal and spatial solution.We are working on accurate sensing and real-time imaging of different biologically relevant molecules (e.g., Caspase, MMPs, GSH, H2S, ALP, β-amyloid) in vivo using multimodal probes and imaging technology.(Angew. Chem. Int. Ed. 2019, 58, 4886; ACS Nano 2016, 10, 10075)
Multimodality Molecular Imaging
(3) Cancer Theranostics
Tumor targeting theranostic probes that integrate molecular imaging and therapeutic functions capable of simultaneous detection and treatment of cancer are very important for cancer diagnosis and therapy. Our third project is working on the design of stimuli responsive theranostic probes that can selectively target to cancer cells and elicit an effective therapeutic response.(J. Am. Chem. Soc. 2018, 140, 16340; Chem. Soc. Rev. 2016, 45, 6725)
