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Lab guide(pdf)

课题组核磁谱图规范要求 (pdf



共享金催化剂 (doc)

Comprehensive Handbook of Chemical Bond Energies (键能书籍)

课题组Treasure Box 20200701







谢劲课题组group presentations

20190318 董洁:金属催化的烯炔硅烷基化进展

20190401 庞玉博:低价Mn催化与配体效应

徐文涛: ????

20190513 李埝:Mn催化的偶联反应









Important publications for group seminar


1. ACIE: The First Gold(III) Formate: Evidence for b-Hydride Elimination [pdf]

2. JACS: Sequential Ruthenium Catalysis for Olefin Isomerization and Oxidation [pdf]


1. JACS: Catalyst-Free and Redox-Neutral Innate Trifluoromethylation and Alkylation of Aromatics Enabled by Light

2. Angew:Medium-ring analogues of dibenzodiazepines by conformationally induced Smiles ring expansion

3. Scienec: Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis


1. Nature Chem. Direct α-C–H bond functionalization of unprotected cyclic amines

2. Nature Chem. Oxidase catalysis via aerobically generated hypervalent iodine intermediates (also see Chem. Commun., 2017,53, 9781-9784)

3. Nature:Site-selective and stereoselective functionalization of non-activated tertiary C–H bonds

2017. 12

1. Nature Chem. A general approach to intermolecular carbonylation of arene C–H bonds to ketones through catalytic aroyl triflate formation

2. light for CF3 C-F activation


Nature Chem. Palladium-catalysed anti-Markovnikov selective oxidative amination

Angew. Chem. A New Portal to SuFEx Click Chemistry

JACS. Hydrogen atom transfer by a high- Hydrogen atom transfer by a high-valent nickel valent nickel valent nickel-chloride complex

Angew. Chem. Manganese Borrowing Hydrogen:

JACS: Synthesis of Allylic Alcohols via Cu-Catalyzed Hydrocarbonylative Coupling of Alkynes with Alkyl Halides

JACS: Remote C–H Hydroxylation by an α-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs


Science: Modular radical cross-coupling with sulfones enables access to sp3-rich (fluoro)alkylated scaffolds

JACS: Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metalate Shift


Selective formation of γ-lactams via C–H amidation enabled by tailored iridium catalysts

Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Enantioselective Intermolecular [2+2] Photocycloaddition Reaction of Cyclic Enones and Its Application in a Synthesis of (−)-Grandisol

Nickel-Catalyzed Umpolung Arylation of Ambiphilic α-Bromoalkyl Boronic Esters

Regioselective Cyclotrimerization of Terminal Alkynes Using a Digermyne

Highly Emissive Fused Heterocyclic Alkynylgold(III) Complexes for Multiple Color Emission Spanning from Green to Red for Solution-Processable Organic Light-Emitting Devices

Catalytic Azoarene Synthesis from Aryl Azides Enabled by a Dinuclear Ni Complex  (DOI: 10.1021/jacs.8b00503) and others from the same group

Oxidative Addition, Transmetalation, and Reductive Elimination at a 2,2′-Bipyridyl-Ligated Gold Center



Nature Chem. A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp3 C−H arylation

Angew. Chem. Photocatalyzed ortho‐Alkylation of Pyridine N‐Oxides through Alkene Cleavage

JACS: Catalytic Diastereo- and Enantioselective Fluoroamination of Alkenes

Nature: Planning chemical syntheses with deep neural networks and symbolic AI

JACS: Deoxyfluorination with Sulfonyl Fluorides: Navigating Reaction Space with Machine Learning

Angew: Iron-Catalyzed Ring-Closing C–O/C–O Metathesis of Aliphatic Ethers

JACS: Conjugate Addition−Enantioselective Protonation of N-Aryl Glycines to α-Branched 2-Vinylazaarenes via Cooperative Photoredox and Asymmetric Catalysis

ANgew: A Bulky Diamine Ligand Promoted Cross-Coupling with Difluoroalkyl Bromides via Iron Catalysis

Angew: Iridium-Catalyzed Sequential Silylation and Borylation of Heteroarenes Based on Regioselective CH Bond Activation

Angew: Catalytic Direct-type Addition Reactions of Alkylarenes with Imines and Alkenes

Angew: Bottom-up Construction of Graphene Segments Based on a PalladiumCatalyzed Annulative Dimerization of o-Iodobiaryl Compounds

JACS: Enantioselective Total Syntheses of Methanoquinolizidine-Containing Akuammiline Alkaloids and Related Studies

JACS: Multimetallic-Catalyzed Oxidative Radical Alkynylation with Termi-nal Alkynes: A New Strategy for C(sp3)-C(sp) Bond Formation

JACS:Radical Carbofluorination of Unactivated Alkenes with Fluoride Ion



NC: Manganese-catalysed benzylic C(sp3)–H amination for late-stage functionalization

Angew: Boronic Acids as Bioorthogonal Probes in SiteSelective Labeling of Proteins

JACS: Direct ß-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade (DOI: 10.1021/jacs.8b03530) ******

JACS: Multi-Metal-Catalyzed Oxidative Radical Alkynylation with Terminal Alkynes: A New Strategy for C(sp3)–C(sp) Bond Formation

(old reaction new catalytic system)

Amgew: Stereospecific Nucleophilic Substitution with Arylboronic Acids asNucleophiles in the Presence of a CONH Group

JACS: Toward Full Zigzag-Edged Nanographenes: peri-Tetracene and Its Corresponding Circumanthracene

Angew:  The N‐Methylpyrrolidone (NMP) Effect in Iron‐Catalyzed Cross‐Coupling with Simple Ferric Salts and MeMgBr

Angew: Metal- and Base-Free Room-Temperature Amination ofOrganoboronic Acids with N-Alkyl Hydroxylamines

JACS: Transition Metal-Free 1,2-Carboboration of Unactivated Alkenes

JACS: Manganese-Mediated Reductive Transamidation of Tertiary Amides with Nitroarenes

JACS: Direct ortho-C—H Aminoalkylation of 2-Substituted Pyridine Derivatives Catalyzed by Yttrium Complexes with N,Nʹ-Diarylethylenediamido Ligands

JACS: Organometallic Gold(III) Reagents for Cysteine Arylation

JACS: Carbon Dioxide Mediated C(sp3)–H Arylation of Amine Substrates

JACS: C-N Cross-Coupling via Photoexcitation of Nickel-Amine Com-plexes

Angew: Catalytic Thorpe-Ingold Effect for Branch-Selective Alkylation of Unactivated Aryl Fluorides

Angew: Manganese Catalyzed Direct Olefination of Methylheteroarenes with Primary Alcohols


June 2018

Angew: Cu-Catalyzed Borocarbonylative Coupling of Internal Alkynes with Unactivated Alkyl Halides: Modular Synthesis of Tetrasubstituted β-Borylenones

Angew: 1,4-Iron Migration for Expedient Allene Annulations through IronCatalyzed CH/NH/CO/CH Functionalizations

Angew: Continuous Visible Light-Photo-Flow for Manganese-Catalyzed (Het)Arene C−H Arylation

Angew: BODIPY Peptide Labeling by Late-Stage C(sp3)‒H Activation

Nature Commun: Nickel-catalyzed reductive thiolation and selenylation of unactivated alkyl bromides

Angew: Access to Secondary and Tertiary Alkyl Boronic Esters via gem-Carboborylation using Carbonyl as Bis(electrophile) Equivalent

Nature Chem: Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases

Angew. Chem.: Thorpe–Ingold Effect in Branch-Selective Alkylation of UnactivatedAryl Fluorides

JACS: Radical Cascade-Triggered Controlled Ring-Opening Polymerization of Macrocyclic Monomers

ACS Catalysis: Visible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes (10.1021/acscatal.8b00707)


Nature Chem: Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals

Nature Comm: Formal enantioconvergent substitution of alkyl halides via catalytic asymmetric photoredox radical coupling

JACS:Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes

JACS: Asymmetric Photocatalytic C–H Functionalization of Toluene and Derivatives

JACS: Chiral Diaryliodonium Phosphate Enables Light Driven Diastereoselective α‑C(sp3 )−H Acetalization

Nature Chem: Complementary site-selectivity in arene functionalization enabled by overcoming the ortho constraint in palladium/norbornene catalysis

Science: Carbonyl catalysis enables a biomimetic asymmetric Mannich reaction 

Angew: Catalytic enantioselective synthesis of chiral azaheteroaryl ethylamines via dearomatizing aza‐Michael/rearomatizing asymmetric protonation


July 2018

Nature Chem.

Nature Chem.

Angew: Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling

Angew: Regiodivergent Synthesis of 1,3‐ and 1,4‐Enynes through Kinetically Favored Hydropalladation and Ligand‐Enforced Carbopalladation

Angew: A Simple, Broad‐Scope Nickel(0) Precatalyst System for the Direct Amination of Allyl Alcohols

JACS: Cu-Catalyzed Aerobic Oxidative N–N Coupling of Carbazoles and Diarylamines Including Selective Cross-Coupling

 (DOI: 10.1021/jacs.8b05245)

JACS: Generation and Alkylation of α-Carbamyl Radicals via Organic Photoredox Catalysis (DOI: 10.1021/jacs.8b04890)

JACS: Intermediacy of Ni–Ni Species in sp2 C–O Bond Cleavage of Aryl Esters: Relevance in Catalytic C–Si Bond Formation


August 2018

Nature Chem. Direct α-alkylation of primary aliphatic amines enabled by CO2 and electrostatics

Nature Chem: Diels–Alder cycloadditions of strained azacyclic allenes

Nature Chem: Hydrogenation catalyst generates cyclic peptide stereocentres in sequence

Nature Chem and JACS: the same chemistry, learn how to design and write an article when the products are not important. Why one can go to Nature Chem and the other can be JACS. Try to compare and find the science behind.


Nature Chem: Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds

Nature Chem: The energy-transfer-enabled biocompatible disulfide–ene reaction

Nature Chem: Activation of diverse carbon–heteroatom and carbon–carbon bonds via palladium(II)-catalysed β-X elimination

Nature: Cooperative asymmetric reactions combining photocatalysis and enzymatic catalysis

JACS: Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes

Angew: Manganese-Catalyzed Redox-Neutral C-H Olefination of Ketoneswith Unactivated Alkenes

Angew: Catalytic Hydrogenation of Cyclic Carbonates using Manganese Complexes

JACS: Enantioselective Trifluoromethylalkynylation of Alkenes via CopperCatalyzed Radical Relay

Angew: Decarboxylative C(sp3 )-O Cross Coupling

JACS: Mechanistic Interrogation of Co/Ni-Dual Catalyzed Hydroarylation

Angew: Backbone-enabled Directional Peptide Macrocyclization through Late-stage Palladium-catalyzed δ-C(sp2 )-H Olefination

Angew: Polymer Donors for High-performance Non-fullerene Organic Solar Cells

JACS: Imidate Radicals (;


September 2018

Angew:  Iridium-Catalyzed α-Selective Arylation of Styrenes by Dual C-H Functionalization

OL: Discovery of Plant Growth Stimulants by C−H Arylation of 2‑Azahypoxanthine

JACS: Cation-π Interactions in the Benzylic Arylation of Toluenes with Bimetallic Catalysts

Angew: Synthesis of Functionalized Cyclopropanes from Carboxylic Acids via a Radical Addition–Polar Cyclization Cascade

JACS: Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy

JACS: Diastereoselective Allylation of Aldehydes by Dual Photoredox and Chromium Catalysis

JACS: Mechanistic Interrogation of Co/Ni-Dual Catalyzed Hydroarylation

Science: Enantiodivergent Pd-catalyzed C–C bond formation enabled through ligand parameterization [pdf]

Angew: Carbonyl-Olefin Cross-Metathesis Through a Visible-Light-Induced 1,3-Diol Formation and Fragmentation Sequence

Science: Interrupted carbonyl-olefin metathesis via oxygen atom transfer (上一篇angew与这篇science下次一起讲,一位同学)

Science: Arylsulfonylacetamides as bifunctional reagents for alkene aminoarylation


Angew: Visible-Light-Induced Pyridylation of Remote C(sp3)–H Bonds by Radical Translocation of N-Alkoxypyridinium Salts



Oct 2018

JACS: Enantioselective Oxidative Coupling of Carboxylic Acids to α‑Branched Aldehydes

JACS: Site-Selective Ni-Catalyzed Reductive Coupling of α‑Haloboranes with Unactivated Olefins

JACS: Light-Driven Intermolecular Charge Transfer Induced Reactivity of Ethynylbenziodoxol(on)e and Phenols

JACS: Catalytic Access to Bridged Sila‑N‑heterocycles from Piperidines via Cascade sp3 and sp2 C−Si Bond Formation

Angew: Platinum-catalyzed Desaturation of Lactams, Ketones and Lactones

Angew: Palladium-Catalysed C–H Alkenylation of Arenes with Alkynes: Stereoselective Synthesis of Vinyl Chlorides via a 1,4-Chlorine Migration

Nature:Base-free nickel-catalysed decarbonylative Suzuki– Miyaura coupling of acid fluorides

Nature: Catalytic enantioconvergent coupling of secondary and tertiary electrophiles with olefins

Science:  Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes



Nov 2018

JACS: Prenyl Praxis: A Method for Direct Photocatalytic Defluoroprenylation

Nature Chemistry: Catalytic activation of unstrained C(aryl)–C(aryl) bonds in 2,2′-biphenols

JACS: Catalytic Regio- and Enantioselective Haloazidation of Allylic Alcohols

JACS: Enol Acetates: Versatile Substrates for the Enantioselective Intermolecular Tsuji Allyation

Angew: gem‐Difluorination of Alkenyl N‐methyliminodiacetyl Boronates: Synthesis of α‐ and β‐Difluorinated Alkylborons


Dec. 2018

Nature Chem. Photochemical generation of radicals from alkyl electrophiles using a nucleophilic organic catalyst

Nature Commun. A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides

Nature: A protein functionalization platform based on selective reactions at methionine residues

Nature Commun. Irradiation-induced palladium-catalyzed decarboxylative desaturation enabled by a dual ligand system

Nature Review. Chem. Modern applications of low-valent early transition metals in synthesis and catalysis

Angew: Oxidative Addition to Palladium(0) Made Easy through Photoexcited‐State Metal Catalysis: Experiment and Computation

Nature Chem. Carbopalladation of C–C σ-bonds enabled by strained boronate complexes

Nature Chem. Chemoselective methylene oxidation in aromatic molecules

Nature Chem. The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation


Jan 2019

JACS: Lead-Halide Perovskites for Photocatalytic α-Alkylation of Aldehydes

JACS: Forging C(sp3)–C(sp3) Bonds with Carbon-Centered Radicals in the Synthesis of Complex Molecules

Angew: C ̶C Bond Formation of Benzyl Alcohols and Alkynes using Catalytic Amount of KOt Bu: Unusual Regioselectivity via a Radical Mechanism

Nature Catalysis: Dual-catalytic transition metal systems for functionalization of unreactive sites of molecules

Angew: Transfer Hydrocyanation of α- and α,β-Substituted Styrenes Catalyzed by Boron Lewis Acids

Angew: Synthesis of Benzofuran Derivatives via Cascade Radical Cyclization/Intermolecular Coupling of 2-Azaallyls

JACS: Catalytic α-Selective Deuteration of Styrene Derivatives

Nature Commun. Olefin-accelerated solid-state C–N cross-coupling reactions using mechanochemistry

JACS:Ni-catalyzed Reductive Liebeskind-Srogl Alkylation of Heterocycles


Feb 2019

Nature: Deacylative transformations of ketones via aromatization-promoted C–C bond activation

Nature Catalysis: A green chemistry perspective on catalytic amide bond formation

Nature Commun: Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives

Science: E-Olefins through intramolecular radical relocation

Science: An enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction

Science: Pharmaceutical diversification via palladium oxidative addition complexes

Angew: Biocatalytic Friedel–Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme

JACS: Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C−C Bond Cleavage

Angew: A Redox Active Nickel Complex that Acts as an Electron Mediator in Photochemical Giese Reactions


March 2019

Nature: Site-selective and versatile aromatic C−H functionalization by thianthrenation

Nature Catalysis: Photoelectrocatalytic arene C–H amination [PDF]

Science: Photocatalytic decarboxylative alkylations mediated by triphenylphosphine and sodium iodide

Science: Catalyst-controlled stereoselectivecationic polymerizationof vinyl ethers


April 2019

Science: Delayed catalyst function enables direct enantioselective conversion of nitriles to NH2-amines

Angew: Late-stage Functionalization of Peptides and Cyclopeptides using Organozinc reagents

JACS: Transition-metal-free C-C, C-O and C-N cross-couplings enabled by light

JACS: Differential Dihydrofunctionalization of Terminal Alkynes: Synthesis of Benzylic Alkyl Boronates through Reductive Three-Component Coupling

JACS: Discovery and Elucidation of Counteranion Dependence in Photoredox Catalysis


May 2019

JACS:Hydroalkylation of Olefins to form Quaternary Carbons

JACS: Carbon Dioxide-Mediated C(sp2 )–H Arylation of Primary and Secondary Benzylamines

Science: Site-selective enzymatic C–H amidation for synthesis of diverse lactams

Nature: Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization

Science: Hydrodealkenylative C(sp3 )–C(sp2 ) bond fragmentation

JACS:Construction of Natural-Product-Like CyclophaneBraced Peptide Macrocycles via sp3 C-H Arylation

Angew: The Persistent Radical Effect in Organic Synthesis

Science: Direct arene C–H fluorination with 18F− via organic photoredox catalysis

Science: Photoexcitation of flavoenzymes enables a stereoselective radical cyclization



JACS: Copper-Catalyzed Decarboxylative Difluoromethylation




JACS:Para-Selective, Iridium-Catalyzed C–H Borylations of Sulfated Phenols, Benzyl Alcohols, and Anilines Directed by Ion-Pair Electrostatic Interactions

Nature Cat.: Tunable catalyst-controlled syntheses of β- and γ-amino alcohols enabled by silver-catalysed nitrene transfer

Nature Chem.:Photosensitized oxidative addition to gold(I) enables alkynylative cyclization of o-alkylnylphenols with iodoalkynes

Angew. Chem.: Acyl-Directed ortho-Borylation of Anilines and C7 Borylation of Indoles using just BBr3

Angew. Chem.: Suzuki–Miyaura Coupling of (Hetero)Aryl Sulfones: Complementary Reactivity Enables Iterative Polyaryl Synthesis


Science:Light-driven deracemization enabled by excited-state electron transfer







©2017 Nanjing University Xie Group