2025
53. Zheng, B.#, Duan, M.#, Huang, Y.#, Wang, S.#, Qiu, J., Lu, Z., Liu, L., Tang, G., Cheng, L.,* Zheng, P.,* Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations. eLife 13, RP100545 (2025) Link · PDF
52. Chong, K. H. C.#, Liu, L.#, Chua, R., Chai, Y. T., Lu, Z., Liu, R., Tan, E. Y. j., Dong, J., Khoh, Y. H., Lin, J., Zhong, F. L., Lescar, J., Zheng, P.,* Wu, B.,* Structural Basis of High-Precision Protein Ligation and Its Application. Journal of the American Chemical Society. (2025) Link · PDF
2024
49. Tang, H.#,* Xiao, Y.#, Qian, L., Wang, Z., Lu, M., Yao, N., Zhou, T., Tian, F., Cao, L., Zheng, P.,* Dong, X.,* Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystal. Journal of Biological Chemistry 300(3), 105765-105775(2024) Link · PDF
47. Zhu, L., Huang, B., Wang, X., Ni, F., Ao, M., Wang, R., Zheng, B., Chen, C., Xue, J., Zhu, L., Yang, C., Shi, L., Geng, S., Hu, J., Yang, M., Zhang, D., Yang, P., Li, M., Li, Y., Hu, Q., Ye, S., Zheng, P., Wei, H., Wu, Z.,* Zhang, L.,* Wang, Y.,* Liu, Y.,* Wu, X.,* Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration. Nature Communications. 15, 6961(2024) Link · PDF
2023
41. Wang, Z., Wang, M., Zhao, Z., Zheng, P.,* Quantification of carboxylate-bridged di-zinc site stability in protein due ferri by single-molecule force spectroscopy. Protein Science 32(3), e4583 (2022) Link · PDF
2022
38. Shi, S.#, Wu, T.#, Zheng P.,* Direct Measurements of the Cobalt-Thiolate Bonds Strength in Rubredoxin by Single-Molecule Force Spectroscopy. ChemBioChem 23, e202200165(2022) ·PDF
OaAEP1-mediated PNA-protein conjugation enables erasable imaging of membrane proteins Chemical Communications 58, 8448-8451 (2022)·PDF
Single-Molecule Force Spectroscopy Reveals the Dynamic HgS Coordination Site in the De Novo-Designed Metalloprotein a3DIV. Journal of Physical Chemistry Letters 13(23), 5372-5378 (2022)·PDF
Detection of weak non-covalent cation-π interactions in NGAL by single-molecule force spectroscopy. ·PDF
33. Shi, S., Wang, Z., Deng, Y., Tian, F., Wu, Q. & Zheng, P.* Combination of SPAAC Click Chemistry and Enzymatic Ligation for Stable and Efficient Protein Immobilization for Single-Molecule Force Spectroscopy, CCS Chemistry 3, 841-847 (2022). Link · PDF
32. Wu, D., Lei, H., Xie, X., Zhou, L., Zheng, P. , Cao, Y.* & Zhang, Y.* Self-sorting double network hydrogels with photo-definable biochemical cues as artificial synthetic extracellular matrix, Nano Research 1-8 (2022) Link · PDF
2021
cited by WHO as guidance for surveillance of SARS-CoV-2 Variants
·PDF
29. Song, G., Tian, F., Liu, H., Li, G. & Zheng, P.* Pioglitazone Inhibits Metal Cluster Transfer of mitoNEET by Stabilizing the Labile Fe-N Bond Revealed at Single-Bond Level. Journal of Physical Chemistry Letters 12, 3860-3867 (2021) Link · PDF
·PDF
27. Yuan, G.,# Curtolo, F.,# Deng, Y.,# Wu, T., Tian, F., Ma, Q., Liu, Y., Zuo, J., Arantes, G. M.* & Zheng, P.* Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule. Research 2021 (2021) Link · PDF
2020
PDF
22. Tian, F., Li, G., Zheng, B., Liu, Y., Shi, S., Deng, Y. & Zheng, P.* Verification of sortase for protein conjugation by single-molecule force spectroscopy and molecular dynamics simulations. Chemical Communications 56, 3943-3946 (2020) Link · PDF
21. Deng, Y., Zheng, B., Liu, Y., Shi, S., Nie, J., Wu, T. & Zheng, P.* OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy. Jove-Journal of Visualized Experiments 156 (2020) Link · PDF
20. Teixeira, M. H., Curtolo, F., Camilo, S. R. G., Field, M. J., Zheng, P., Li, H. & Arantes, G. M. Modeling the Hydrolysis of Iron-Sulfur Clusters. Journal of Chemical Information and Modeling 60, 653-660 (2020) Link · PDF
2019
19. Deng, Y., Wu, T., Wang, M., Shi, S., Yuan, G., Li, X., Chong, H., Wu, B. & Zheng, P.* Enzymatic biosynthesis and immobilization of polyprotein verified at the single-molecule level. Nature Communications 10, 2775(2019) Link· PDF
18. Yuan, G., Liu, H., Ma, Q., Li, X., Nie, J., Zuo, J. & Zheng, P.* Single-Molecule Force Spectroscopy Reveals that Iron-Ligand Bonds Modulate Proteins in Different Modes. Journal of Physical Chemistry Letters 10, 5428-5433 (2019) Link ·PDF
17. Yin, Z., Song, G., Jiao, Y., Zheng, P., Xu, J. & Zhang, X., Dissipative Supramolecular Polymerization Powered by Light, CCS Chemistry 1, 335-342 (2019) Link·PDF
16. 李劼; 郑鹏; 赵劲; 陈鹏; 郭子建 ; 金属介导的免疫调控与干预:金属免疫学的兴起与展望, 中国科学:化学, 2019, 49(08): 1037-1046
15. Yuan, G., Ma, Q., Wu, T., Wang, M., Li, X., Zuo, J. & Zheng, P.* Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd3S9. Scientific Reports 9 (2019) Link · PDF
14. Lai, J.-C., Jia, X.-Y., Wang, D.-P., Deng, Y.-B., Zheng, P., Li, C.-H., Zuo, J.-L. & Bao, Z. Thermodynamically stable whilst kinetically labile coordination bonds lead to strong and tough self-healing polymers. Nature Communications 10, 1164 (2019) Link · PDF
13. Zhang, Z., Huang, Q., Tao, X., Song, G., Zheng, P., Li, H., Sun, H. & Xia, W. The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping. Journal of Biological Chemistry 294, 7990-8000 (2019) Link · PDF
2018
12. Li, H. & Zheng, P. Single molecule force spectroscopy: a new tool for bioinorganic chemistry. Current Opinion in Chemical Biology 43, 58-67 (2018) Link · PDF
2016
11. Li, C.-H., Wang, C., Keplinger, C., Zuo, J.-L., Jin, L., Sun, Y., Zheng, P., Cao, Y., Lissel, F., Linder, C., You, X.-Z. & Bao, Z. A highly stretchable autonomous self-healing elastomer. Nature Chemistry 8, 619-625 (2016) Link · PDF
2015
10. Zheng, P., Arantes, G. M., Field, M. J. & Li, H. Force-induced chemical reactions on the metal centre in a single metalloprotein molecule. Nature Communications 6, 7569 (2015) Link · PDF
2014 and Before
9. Zheng, P., Wang, Y. & Li, H. Reversible Unfolding-Refolding of Rubredoxin: A Single-Molecule Force Spectroscopy Study. Angewandte Chemie-International Edition 53, 14060-14063 (2014) Link · PDF
8. Zheng, P., Takayama, S.-i. J., Mauk, A. G. & Li, H. Single Molecule Force Spectroscopy Reveals That Iron Is Released from the Active Site of Rubredoxin by a Stochastic Mechanism. Journal of the American Chemical Society 135, 7992-8000 (2013) Link · PDF
7. Zheng, P., Chou, C.-C., Guo, Y., Wang, Y. & Li, H. Single Molecule Force Spectroscopy Reveals the Molecular Mechanical Anisotropy of the FeS4 Metal Center in Rubredoxin. Journal of the American Chemical Society 135, 17783-17792 (2013) Link · PDF
6. Zheng, P., Takayama, S.-i. J., Mauk, A. G. & Li, H. Hydrogen Bond Strength Modulates the Mechanical Strength of Ferric-Thiolate Bonds in Rubredoxin. Journal of the American Chemical Society 134, 4124-4131, (2012) Link · PDF
5. Li, Y. D., Lamour, G., Gsponer, J., Zheng, P. & Li, H. The Molecular Mechanism Underlying Mechanical Anisotropy of the Protein GB1. Biophysical Journal 103, 2361-2368 (2012) Link · PDF
4. Zheng, P. & Li, H. Highly Covalent Ferric-Thiolate Bonds Exhibit Surprisingly Low Mechanical Stability. Journal of the American Chemical Society 133, 6791-6798 Link · PDF
3. Zheng, P. & Li, H. Direct Measurements of the Mechanical Stability of Zinc-Thiolate Bonds in Rubredoxin by Single-Molecule Atomic Force Microscopy. Biophysical Journal 101, 1467-1473 (2011) Link · PDF
2. Zheng, P., Cao, Y. & Li, H. Facile Method of Constructing Polyproteins for Single-Molecule Force Spectroscopy Studies. Langmuir 27, 5713-5718 (2011) Link · PDF
1. Zheng, P., Cao, Y., Bu, T., Straus, S. K. & Li, H. Single Molecule Force Spectroscopy Reveals that Electrostatic Interactions Affect the Mechanical Stability of Proteins. Biophysical Journal 100, 1534-1541 (2011) Link · PDF