• 2024


    • 47. Tang, H.#,* Xiao, Y.#, Qian, L., Wang, Z., Lu, M., Yao, N., Zhou, T., Tian, F., Cao, L., Zheng, P.,* Dong, X.,* Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystal. Journal of Biological Chemistry, 2024 Link · PDF

    • 46. Wang, Z., Xie, D., Li, J., Zhai, Z., Lu, Z., Tian, X., Niu, Y., Zhao, Q., Zheng, P.,* Dong, L.,* Wang, C.,* Molecular force-induced liberation of transforming growth factor-beta remodels the spleen for ectopic liver regeneration. Journal of Hepatology2024 Link · PDF

  • 2023


    • 45. Xiao, Y., Zheng, B., Ding, X., Zheng, P.,* Probing nanomechanical interactions of SARS-CoV-2 variants Omicron and XBB with common surfaces. Chemical Communications 59(75), 11268-11271(2023)  Link · PDF

    • 44. Zheng, B., Xiao, Y., Tong, B., Mao, Y., Ge, R., Tian, F., Dong, X., Zheng, P.,*  S373P Mutation Stabilizes the Receptor-Binding Domain of the Spike Protein in Omicron and Promotes Binding. JACS Au 3(7), 1902–1910 (2023)  Link · PDF

    • 43. Nie, J.#, Wang, Z.#, Wang, M., Zheng, P., *  Effect of the Competing Ligand on Ni-NTA/Histag Strength Revealed by Click Chemistry-Based Force Spectroscopy. The Journal of Physical Chemistry Letters 14(23), 5426-5431 (2023)  Link · PDF

    • 42. Wang, Z., Zhao, Z., Yang, Z., Li, G., Zheng, P.,* pH-Dependent PdS3 Site in α3DIV Revealed by Single-Molecule Force Spectroscopy. Journal of Physical Chemistry B 127(13), 2934-2940 (2023)  Link ·PDF

    • 41. Wang, Z., Wang, M., Zhao, Z., Zheng, P.,* Quantification of carboxylate-bridged di-zinc site stability in protein due ferri by single-molecule force spectroscopy. Protein Science 32(3), e4583 (2022)  Link · PDF

    • 40. Zhang, S., Deng, Y., Libanori, A., Zhou, Y., Yang, J., Tat, T., Yang, L., Sun, W., Zheng, P., Zhu, Y.-L., Chen, J. and Tan, S.C., In Situ Grown Silver–Polymer Framework with Coordination Complexes for Functional Artificial Tissues. Advanced Materials 35: 2207916 (2023)  Link · PDF

    • 39. Zhang, S., Zhou, Y., Libanori, A., Deng, Y., Liu, M., Zhou, M., Qu, H., Zhao, X., Zheng, P., Zhu, Y.-L., Chen, J., & Tan, S. C., Biomimetic spinning of soft functional fibres via spontaneous phase separation. Nature Electronics 6(5), 338-348 (2023)   Link · PDF

  • 2022


    • 38. Shi, S.#, Wu, T.#Zheng P.,* Direct Measurements of the Cobalt-Thiolate Bonds Strength in Rubredoxin by Single-Molecule Force Spectroscopy. ChemBioChem 23, e202200165(2022) Link ·PDF

    • 37. Lu, Z.#, Liu, Y.#, Deng,Y., Jia, B., Ding, X., Zheng, P.,* & Li, Z.* OaAEP1-mediated PNA-protein conjugation  enables  erasable imaging of membrane proteins Chemical Communications 58, 8448-8451 (2022) Link·PDF

    • 36. Wang, Z., Zhao, Z., Li, G., Zheng, P.,* Single-Molecule Force Spectroscopy Reveals the Dynamic HgS Coordination Site in the De Novo-Designed Metalloprotein a3DIV. Journal of Physical Chemistry Letters 13(23), 5372-5378 (2022) Link·PDF

    • 35. Tong, B.#, Tian, F.#Zheng, P.,* Interdomain Linker Effect on the Mechanical Stability of Ig Domains in Titin. International Journal of Molecular Sciences 23, 9836-9845 (2022) Link·PDF

    • 34. Nie, J., Deng, Y., Tian, F., Shi, S., Zheng, P.,* Detection of weak non-covalent cation-π interactions in NGAL by single-molecule force spectroscopy. Nano Research  71, 4251-4257 (2022) Link·PDF

    • 33. Shi, S., Wang, Z., Deng, Y., Tian, F., Wu, Q. & Zheng, P.* Combination of SPAAC Click Chemistry and Enzymatic Ligation for Stable and Efficient Protein Immobilization for Single-Molecule Force SpectroscopyCCS Chemistry 3, 841-847 (2022). Link · PDF

    • 32. Wu, D., Lei, H., Xie, X., Zhou, L., Zheng, P. , Cao, Y.* & Zhang, Y.* Self-sorting double network hydrogels with photo-definable biochemical cues as artificial synthetic extracellular matrixNano Research 1-8 (2022) Link · PDF



    • 31. Tian, F.,# Tong, B.,# Sun, L., Shi, S., Zheng, B., Wang, Z., Dong, X.,* & Zheng, P.,* N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2. eLife 10, e69091 (2021) Link · PDF

      cited by WHO as guidance for surveillance of SARS-CoV-2 Variants

    • 30. Liu, Y.#, Tian, F.#, Shi, S., Deng, Y., Zheng, P.,* Enzymatic Protein–Protein Conjugation through Internal Site Verified at the Single-Molecule Level. Journal of Physical Chemistry Letters 12, 10914-10919 (2021) Link·PDF

      29. Song, G., Tian, F., Liu, H., Li, G. & Zheng, P.* Pioglitazone Inhibits Metal Cluster Transfer of mitoNEET by Stabilizing the Labile Fe-N Bond Revealed at Single-Bond Level. Journal of Physical Chemistry Letters 12, 3860-3867 (2021Link · PDF

      28. Wang, Z., Nie, J., Shi, S., Li, G., Zheng, P.,* Transforming de novo protein α3D into a mechanically stable protein by zinc binding. Chemical Communications 57, 11489-11492 (2021) Link·PDF

      27. Yuan, G.,# Curtolo, F.,# Deng, Y.,# Wu, T., Tian, F., Ma, Q., Liu, Y., Zuo, J., Arantes, G. M.* Zheng, P.Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule. Research 2021 (2021) Link · PDF

      26. Nie, J., Tian, F., Zheng, B., Wang, Z. & Zheng, P.* Exploration of Metal-Ligand Coordination Bonds in Proteins by Single-Molecule Force Spectroscopy. Chemistry Letters 50, 1667-1675 (2021) Link · PDF

    • 25. Ma, Q., Liu, L., Yang, Z., Zheng, P.,* Facile Synthesis of Peptide-Conjugated Gold Nanoclusters with Different Lengths.Nanomaterials 11, 2932 (2021) Link·PDF

      24. Yin, Z., Yang, Y., Yang, J., Song, G., Hu, H., Zheng, P., & Xu, J.,* Supramolecular Polymerization Powered by Escherichia coli: Fabricating a Near-Infrared Photothermal Antibacterial Agent in Situ. CCS Chemistry (2021) Link·PDF

    • 2020


      23. Song, G., Ding, X., Liu, H., Yuan, G., Tian, F., Shi, S., Yang, Y., Li, G. & Zheng, P.* Single-Molecule Force Spectroscopy Reveals that the Fe-N Bond Enables Multiple Rupture Pathways of the 2Fe2S Cluster in a MitoNEET Monomer. Analytical Chemistry 92, 14783-14789 (2020) Link · PDF

      22. Tian, F., Li, G., Zheng, B., Liu, Y., Shi, S., Deng, Y. & Zheng, P.* Verification of sortase for protein conjugation by single-molecule force spectroscopy and molecular dynamics simulations. Chemical Communications 56, 3943-3946 (2020) Link · PDF

      21. Deng, Y., Zheng, B., Liu, Y., Shi, S., Nie, J., Wu, T. & Zheng, P.* OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy. Jove-Journal of Visualized Experiments 156 (2020) Link · PDF

      20. Teixeira, M. H., Curtolo, F., Camilo, S. R. G., Field, M. J., Zheng, P., Li, H. & Arantes, G. M. Modeling the Hydrolysis of Iron-Sulfur Clusters. Journal of Chemical Information and Modeling 60, 653-660 (2020) Link · PDF



      19. Deng, Y., Wu, T., Wang, M., Shi, S., Yuan, G., Li, X., Chong, H., Wu, B. & Zheng, P.* Enzymatic biosynthesis and immobilization of polyprotein verified at the single-molecule level. Nature Communications 10, 2775(2019) Link· PDF

      18. Yuan, G., Liu, H., Ma, Q., Li, X., Nie, J., Zuo, J. & Zheng, P.* Single-Molecule Force Spectroscopy Reveals that Iron-Ligand Bonds Modulate Proteins in Different Modes. Journal of Physical Chemistry Letters 10, 5428-5433 (2019) Link ·PDF

      17. Yin, Z., Song, G., Jiao, Y., Zheng, P., Xu, J. & Zhang, X., Dissipative Supramolecular Polymerization Powered by Light, CCS Chemistry 1, 335-342 (2019) Link·PDF


    • 16. 李劼; 郑鹏; 赵劲; 陈鹏; 郭子建 ; 金属介导的免疫调控与干预:金属免疫学的兴起与展望, 中国科学:化学, 2019, 49(08): 1037-1046 

    • 15. Yuan, G., Ma, Q., Wu, T., Wang, M., Li, X., Zuo, J. & Zheng, P.* Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd3S9Scientific Reports 9 (2019) Link  · PDF

      14. Lai, J.-C., Jia, X.-Y., Wang, D.-P., Deng, Y.-B., Zheng, P., Li, C.-H., Zuo, J.-L. & Bao, Z. Thermodynamically stable whilst kinetically labile coordination bonds lead to strong and tough self-healing polymers. Nature Communications 10, 1164 (2019) Link · PDF

    • 13. Zhang, Z., Huang, Q., Tao, X., Song, G., Zheng, P., Li, H., Sun, H. & Xia, W. The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping. Journal of Biological Chemistr294, 7990-8000 (2019) Link · PDF



      12. Li, H. & Zheng, P. Single molecule force spectroscopy: a new tool for bioinorganic chemistry. Current Opinion in Chemical Biology 43, 58-67 (2018) Link · PDF



      11. Li, C.-H., Wang, C., Keplinger, C., Zuo, J.-L., Jin, L., Sun, Y., Zheng, P., Cao, Y., Lissel, F., Linder, C., You, X.-Z. & Bao, Z. A highly stretchable autonomous self-healing elastomer. Nature Chemistry 8, 619-625 (2016) Link · PDF



      10. Zheng, P., Arantes, G. M., Field, M. J. & Li, H. Force-induced chemical reactions on the metal centre in a single metalloprotein molecule. Nature Communications 6, 7569 (2015) Link · PDF

      2014 and Before


      9. Zheng, P., Wang, Y. & Li, H. Reversible Unfolding-Refolding of Rubredoxin: A Single-Molecule Force Spectroscopy Study. Angewandte Chemie-International Edition 53, 14060-14063 (2014) Link · PDF

      8. Zheng, P., Takayama, S.-i. J., Mauk, A. G. & Li, H. Single Molecule Force Spectroscopy Reveals That Iron Is Released from the Active Site of Rubredoxin by a Stochastic Mechanism. Journal of the American Chemical Society 135, 7992-8000 (2013Link ·  PDF

      7. Zheng, P., Chou, C.-C., Guo, Y., Wang, Y. & Li, H. Single Molecule Force Spectroscopy Reveals the Molecular Mechanical Anisotropy of the FeS4 Metal Center in Rubredoxin. Journal of the American Chemical Society 135, 17783-17792 (2013Link · PDF

      6. Zheng, P., Takayama, S.-i. J., Mauk, A. G. & Li, H. Hydrogen Bond Strength Modulates the Mechanical Strength of Ferric-Thiolate Bonds in Rubredoxin. Journal of the American Chemical Society 134, 4124-4131, (2012Link · PDF

      5. Li, Y. D., Lamour, G., Gsponer, J., Zheng, P. & Li, H. The Molecular Mechanism Underlying Mechanical Anisotropy of the Protein GB1. Biophysical Journal 103, 2361-2368 (2012Link · PDF

      4. Zheng, P. & Li, H. Highly Covalent Ferric-Thiolate Bonds Exhibit Surprisingly Low Mechanical Stability. Journal of the American Chemical Society 133, 6791-679Link · PDF

      3. Zheng, P. & Li, H. Direct Measurements of the Mechanical Stability of Zinc-Thiolate Bonds in Rubredoxin by Single-Molecule Atomic Force Microscopy. Biophysical Journal 101, 1467-1473 (2011Link · PDF

      2. Zheng, P., Cao, Y. & Li, H. Facile Method of Constructing Polyproteins for Single-Molecule Force Spectroscopy Studies. Langmuir 27, 5713-5718 (2011Link · PDF

      1. Zheng, P., Cao, Y., Bu, T., Straus, S. K. & Li, H. Single Molecule Force Spectroscopy Reveals that Electrostatic Interactions Affect the Mechanical Stability of Proteins. Biophysical Journal 100, 1534-1541 (2011) Link · PDF

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