The Yao Group

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[2020-08-16] Celebrating Prof.Yao's 52nd birthday in Nanjing!
[2020-08-05] 祝贺顾越飞同学硕士答辩圆满完成!
[2020-08-05] YL064 activates proteasomal-dependent degradation of c-Myc and synergistically enhances the anti-tumor activity of ABT-199 in diffuse large B cell lymphoma has been published on Signal Transduction and Targeted Therapy.
[2020-08-05] New triterpenoid saponin glycosides from the fruit fibers of Trichosanthes cucumerina L. has been accomplished by Parichat Suebsakwong, Wanatsanan Chulrik and et al. For details, pleased read RSC Adv., 2020, 10, 10461–10470 (DOI:10.1039/d0ra01176b).
[2020-08-05] An eight-step total synthesis of pyrroloquinolone-type Lycopodium alkaloid via a tandem annulation approach has been accomplished by Zhong Linrui, Yang Yuanjie and et al. For details, pleased read Chin. J. Chem. 2020, 38, 10.1002/cjoc.202000273.
[2020-08-05] A gram-scale laboratory synthesis of Annonaceous acetogenin mimic AA005 has been accomplished by Yu Baobao. For details, please read Chin. Chem. Lett.(2020), https://doi.org/10.1016/j.cclet.2020.06.007.
[2020-08-05] Scalable Cu(II)-mediated intramolecular dehydrogenative phenol-phenol coupling: Concise synthesis of enantiopure axially chiral homo- and hetero-diphenols has been accomplished by Gu Yuefei and et al. Please click for details.
[2019-09-22] Diastereoselective Synthesis of Polysubstituted Piperidines via Visible Light-Driven Silylative Cyclization of Aza-1,6-Dienes: Experimental and DFT Studies has been accomplished by Wei-Chen Cui. Wenxuan Zhao and et al. For details, please read Chem.
[2019-09-10] A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model has been accomplished by Parichat Suebsakwong, Jie Wang and et al. For details, please read ACS Med. Chem. Lett. 2019, 10, 1400-1406.(DOI:10.
[2019-07-01] Divergent Synthesis of Oxa-Cyclic Nitrones through Gold(I)-Catalyzed 1,3-Azaprotio Transfer of Propargylic α-Ketocarboxylate Oximes: Experimental and DFT Studies has been accomplished by Wang Chunhong, Cui Qi,and et al. For details, please read Chem
[2019-05-22] 祝贺崔维琛同学博士答辩圆满完成!
[2019-03-30] Enjoy Spring Scene at Xuanwu Lake!
[2019-03-30] 祝贺朱晶同学博士答辩圆满完成!
[2018-11-12] 祝贺高铭同学博士答辩圆满完成!
[2018-11-12] 祝贺魏军强同学硕士答辩圆满完成!
[2018-10-31] Visible Light-Driven Radical trans-Hydrosilylation of Electron-Neutral and -Rich Alkenes with Tertiary and Secondary Hydrosilanes has been accomplished by Jing Zhu, Weichen Cui,and et al. For details, please read J. Org. Chem. 2018,83,14600-14609.(
[2018-10-04] 11‐Aza‐artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6) has been accomplished by Xinya Chen, Yue Yin,and et al. For details, please read Chin. J. Chem. 2018, 36, 1197-1201.(DOI:10.1002/cjoc.
[2018-10-04] Enjoy the Snow Scene
[2018-10-03] YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells has been accomplished by Yingying Wang, Linlin Wu,and et al. For details, please read Cell Death Discovery (2019) 5:44(DOI 10.1038/s41420-018-0108-8)
[2018-08-15] Enantioselective Total Synthesis of (+)-Plumisclerin A has been accomplished by Ming Gao, and et al. For details, plesae read Angew. Chem. Int. Ed. 2018,57,13313-13318(DOI:10.1002/anie.201808517)
[2018-08-12] Celebrating Prof.Yao's 50th birthday in Nanjing!
[2018-07-28] Participating in the CCS 12th National Symposium on Natural Organic Chemistry
[2018-06-19] Annonaceous acetogenin mimic AA005 suppresses human colon cancer cell growth in vivo through downregulation of Mcl-1 has been accomplished by Bing Han,and et al. For details, please read Acta Pharmacologica Sinica(2019)40:231-242(DOI:10.1038/s41401-
[2018-06-06] Radical Hydrosilylation of Alkynes Catalyzed by Eosin Y and Thiol under Visible Light Irradiation has been accomplished by Jing Zhu, Weichen Cui,and et al. For details, please read Org. Lett. 2018, 20, 3174−3178(DOI: 10.1021/acs.orglett.8b00909)
[2018-03-31] Spring tour at Xuanwu Lake
[2017-08-18] Synthesis of 2,3-Dialkylated Tartaric Acid Esters via Visible Light Photoredox-Catalyzed Reductive Dimerization of α‑Ketoesters has been reviewed by Jing Zhu,and et al. For details, please read ACS Omega 2017, 2, 4665−4677(DOI:10.1021/acsomega.7b0074
[2017-05-21] 祝贺袁意、郭涛、陈港港同学硕士毕业答辩圆满完成!
[2017-03-21] Recent advances in direct dehydrogenative biphenyl couplings has been reviewed by Fei Lv,and et al. For details, please read SCIENCE CHINA Chemistry. 2017. 60, 701-720 (DOI:10.1007/s11426-016-0435-5)
[2017-03-21] Hanami at Xuanwu Lake
[2017-01-13] Azepinoindole Synthesis via a N‑Bromosuccinimide-Induced Cycloisomerization of Enaminoester/Enaminone has been accomplished by Lina Chang,and et al. For details, please read J. Org. Chem. 2017, 82, 1567−1574 (DOI:10.1021/acs.joc.6b02760)
[2017-01-04] Nodupetide, a potent insecticide and antimicrobial from Nodulisporium sp. associated with Riptortus pedestris has been accomplished by Li Ping Lin,and et al. For details, please read Tetrahedron Letters. 2017, 58, 663–665(DOI.org/10.1016/j.tetlet.201
[2016-11-22] Welcome Joy Ghrayche as part of one month short term exchange program between Nanjing University and The University of Sydney (Australia)
[2016-11-05] Participating in the Fourteenth Session of the Jiang Huai Organic Forum
[2016-08-02] Michael addition-based cyclization strategy in the total synthesis of Lycopodium alkaloids has been reviewed by Lin-Rui Zhong,and et al. For details, please read SCIENCE CHINA Chemistry. 2016. 59, 1079-1087 (DOI:10.1007/s11426-016-0056-0)
[2016-08-02] Michael addition-based cyclization strategy in the total synthesis of Lycopodium alkaloids has been reviewed by Lin-Rui Zhong,and et al. For details, please read SCIENCE CHINA Chemistry. 2016. 59, 1079-1087 (DOI:10.1007/s11426-016-0056-0)
[2016-06-23] Gram-Scale Laboratory Synthesis of UM171, a Potent Agonist of Human Hematopoietic Stem Cell Self-Renewal has been accomplished by Sajjad Ali,and et al. For details, please read J. Org. Chem. 2016, 81, 10236−10241 (DOI:10.1021/acs.joc.6b01094)
[2016-05-24] 祝贺吴霖霖、吕飞同学硕士毕业答辩圆满完成!
[2016-05-22] Aerobic a-hydroxylation of b-keto esters and amides by co-catalysis of SmI3 and I2 under mild base-free conditions, has been accomplished by Shun-Ming Yu, and et al. For details, please read Tetrahedron. Letters. 2016. 57. 2818-2821 (DOI:10.1016/j.t
[2016-03-23] Enjoy flowers in a spring outing
[2016-03-15] Convenient One-Step Synthesis of Benzo[c]phenanthridines by Three-Component Reactions of Isochromenylium Tetrafluoroborates and Stilbenes in Acetonitrile, has been accomplished by Gang-Gang Chen, and et al. For details, please read Org. Lett. 2016, 1
[2016-02-12] Enantioselective Total Synthesis of Lycoposerramine‑Z Using Chiral Phosphoric Acid Catalyzed Intramolecular Michael Addition,has been accomplished by Zhang Lan-De, and et al. For details, please read J. Org. Chem. 2016, 81, 1899–1904(DOI:10.1021/acs.
[2015-09-25] Kinetic or Dynamic Control on a Bifurcating Potential Energy Surface?An Experimental and DFT Study of Gold-Catalyzed Ring Expansion and Spirocyclization of 2-Propargyl-β-tetrahydrocarbolines,has been accomplished by Zhang Lei, and et al. For details
[2015-09-01] Welcome Nishikawa as part of three month-long short term exchange program between Nanjing University and Tohoku University (Japan)
[2015-07-29] Synthesis of Tricyclo[4,3,1,01,5]decane Core of Plumisclerin A Using Pauson–Khand Annulation and SmI2-Mediated Radical Cyclization, has been accomplished by Chen Ji-Peng, and et al. For details,please read Org. Lett. 2015, 17, 3379-3381(DOI:10.102
[2015-07-22] Efficient Synthesis of Octahydrophenanthrene Derivatives with Mild Cascade Reactions of Isochromenylium Tetrafluoroborates and Bifunctional Styrenes , has been accomplished by Mo Lei, Wu Lin-Lin, and et al. For details, please read Org. Lett. 2015, 1
[2015-07-22] 祝贺莫磊同学博士毕业答辩圆满完成!
[2015-05-19] 祝贺张磊同学博士毕业答辩圆满完成!
[2015-05-19] 祝贺单乃玉、常利娜同学硕士毕业答辩圆满完成!
[2015-04-01] A convergent protecting group-free total synthesis route of camptothecin and 10-hydroxycamptothecin has been developed Xu Peng, and et al.For details, please read Chem. Asian J. 2015, 10, 976-981 (DOI: 10.1002/asia.201403190).
[2015-03-25] Hanami at Xuanwu Lake.

Office E515, Lab B505 511 512, School of Chemistry and Chemical Engineering , State Key Laboratory of Coordination Chemistry and Nanjing National Laboratory of Microstructures

Tel: +86-25-89683732 E-mail: yaoz@nju.edu.cn Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu, China