Imaging of biomolecules in living cells and living animals is a practical strategy for investigation of the biomolecules as well as for cancer detection. We are now developing multi-functional probes that can target cancer-related miRNAs, proteases or other biomolecules for fluorescence imaging of them with high specificity and sensitivity. (Chem. Commun. 2017, 53, 6422; ACS Nano 2016, 10, 10075;  Chem. Commun. 2016, 52, 2342; Chem. Eur. J. 2015, 21, 10506).