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Fluorescence sensors development and application
Nanobiosensors development and application
Interactions between biomacromolecules and metal ions and organic small molecules
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Fluorescence sensors development and application

   发布时间:2015-08-29    作者:王志林    浏览量:11
 

The development of highly selective and sensitive fluorescent sensors has received considerable attention owing to their utility in clarifying and analyzing the roles of ions and biomolecules in living systems. A series  of water-soluble fluorescent sensors based on the pyridine-containing tetraazamacrocycle were designed and synthesized, which show high selectivity and sensitivity for ratiometric recognition Of Cu2 , Zn2 , Hg2 ,  pyrophosphate, calf thymus DNA and bovine serum albumin, respectively. Wherein, an NBD-armed tetraazamacrocyclic fluorescent probe was specifically localized in lysosomes and successfully applied to visualize Cu2  as well as to monitor Cu2  level change in the lysosomes of living cells. A Zn2  tetraazamacrocycle complex bearing three naphthalene moieties recognizes binds and causes damage to DNA, and shows considerable cytotoxicity against human cancer cell lines with a different apoptotic pathway from that of cisplatin.