| People

P.I.Deju Ye, Ph. D.

Professor, School of Chemistry & Chemical Engineering, Nanjing University

2015-Present: Professor, Nanjing University 

2014-2015, Associate Professor, Nanjing University

2009-2014, Postdoc, School of Medicine, Stanford University

2004-2009: Ph.D., Shanghai Institute of Meteria Medica, Chinese Academy of Sciences 

2000-2004: BS, School of Chemistry & Chemical Engineering, Nanjing University

 

 

Brief biography

Dr. Ye received B. S. in Chemistry from Nanjing University in 2004. Received Ph.D. in Drug Design and Medicinal Chemistry with Prof. Hualiang Jiang and Prof. Hong Liu from SIMM (CAS) in 2009, with dissertation of “Drug Design, Synthesis and Pharmacological Research of Privileged Structures”. Post-doctoral training in Prof. Jianghong Rao lab in Molecular Imaging Program at Stanford University (MIPS) from 2009 to 2014, where he developed multimodality molecular imaging probes for non-invasive detection of protease activity in vivo . 

He moved back to China and joined in Nanjing University as an associated professor in Oct 2014, and then promoted to full professor in Jun 2015. Research interests focus on the development of activatable multimodality molecular imaging probes for non-invasive detection of biomolecules both in cells and in living animals. Published more than 40 SCI papers, including Nat. Chem., Angew. Chem. Int. Ed., Chem. Soc. Rev., and Anal. Chem. Applied 4 patents. His work has been highlighted as ACS Editor Choice, highlighted lecture, highly cited paper, and so on. He has won honors and awards including “Young Thousand Talent in China” (2015),  IAAM Scientist Medal (2016), Young investigator travel award (2013) and Excellent graduate student of CAS (2009).

 

Teaching

  • Nano-Analytical Chemistry 《纳米分析化学》,for graduate students
  • Chemical Biology 《化学生物学导论》with Prof. Huang Wang, for both graduate and undergraduate students
  • Instrumental Analysis Experiment 《仪器分析实验》, for undergraduate students and Ph.D. student

Ruibing An (安瑞冰), M.S.

  Education:

  Sep 2016–Present: Ph.D Candidate in Analytical Chemistry,

               School of Chemistry and Chemical Engineering,

               Nanjing University. 

  Sep 2013–Jul 2016: M.S. in Organic Chemistry,

                School of Chemistry and Pharmaceutical Engineering,

                Qilu University of Technology.

  Sep 2009–Jul 2013: B.S. in Chemistry,

                School of Chemistry and Pharmaceutical Engineering,

                Taishan Medical University.

  Email: anruibing2015@163.com

  Tel: 025-89681915

  Ad: Rm A-523, Chemical Building

 

My personal profile: Nothing in life is to be fraid. It is only to be understood.

My research interests include chemical sensors, synthetic chemistry and multimodality imaging probes.

 

Yidan Sun (孙一丹), B.S.

  Education:

  Sep 2016–Present: Ph.D. candidate in analytical chemistry,

               School of Chemistry and Chemical Engineering,

               Nanjing University.                                                                

  Sep 2012-Jul 2016: B.S. in Chemistry,

               School of Chemistry and Chemical Engineering,

               Nanjing University.

  Email: yidansun0105@outlook.com

  Tel: 025-89691915

  Ad: Rm A-523, Chemical Building

 

 

 

My personal profile: I like studying analytical chemistry with nano-probes and nano-technique.

I am designing nano-probes for multimodality imaging and cancer therapy in living cells and in live animals.

 

Yuxuan Hu (胡宇轩), B.S.

  Education: 

  Sep 2016–Present:   Ph.D. Candidate in School of Chemistry and Chemical Engineering, 

                  Nanjing University.                                                                 

  Sep 2012–Jul 2016:  B.S. in Chemistry, School of Chemistry and Chemical Engineering,

                 Nanjing University.

  Email: huyuxuan0225@163.com

  Tel: 025-89681915

  Ad: Rm A-523

 

 

 

My personal profile: Interests are anchors, and I believe they will bring peace and even happiness in the end.

I am developing self-assembling probes for multimodality imaging and drug delivery in living cells and in live animals.

 

Publications:

1. M. Zheng, Y. Wang, H. Shi, Y. Hu, L. Feng, Z. Luo, M. Zhou, J. He, Y. Zhou, Y. Zhang and D. Ye. Redox-mediated disassembly to build activatable trimodal probe for molecular imaging of biothiols. ACS Nano. 2016, 10 (11), 10075–10085

Shi Hua (施桦),

  Education:

  Sep 2016–Present: Ph.D. Candidate in Medicine, Medical School,

                Nanjing University.

               Supervisor: Prof. Zhengyang Zhou

  Sep 2014–Jul 2016:  M.D. in Medicine, Medical School,

                 Nanjing University.

                 Supervisor: Prof. Zhengyang Zhou

  Sep 2009–Jul 2014:  B.S. in Medicine, Medical School,

                 Nanjing University.

  Email: shihuabella@126.com

  Tel: 025-89681916

  Ad: Rm A-526, Chemical Building

 

My personal profile: I like medicine, especially to discover new methods for tumor detection. I more like staying with my family, to enjoy sunshine or hear raindrops together.

I am developing nanoprobes for multimodality imaging of tumor cells in living live animals.

 

Publications:

1. Yue Guan#, Hua Shi#, Ying Chen, Song Liu, Weifeng Li, Zhuoran Jiang,  Huanhuan Wang, Jian He*, Zhengyang Zhou*, Yun Ge*, Whole-Lesion Histogram Analysis of Apparent Diffusion Coefficient for the Assessment of Cervical Cancer, J Comput Assist Tomogr. 2015 Dec 30.

2. Jian He#, Hua Shi#, Zhuping Zhou, Jun Chen, wenxian Guan, Hao Wang, Song Liu*, Zhengyang Zhou*, Xiaofeng Yang, Tian Liu, Correlation between apparent diffusion coefficients and HER2 status in gastric cancers: pilot study, BMC Cancer, 2015, Oct 20;15:749.

3. Mengmeng Zheng#; Yuqi Wang#; Hua Shi; Yuxuan Hu; Liandong Feng; Zhiliang Luo; Mi Zhou; Jian He; Zhengyang Zhou *; Yan Zhang *; Deju Ye *. Redox-Mediated Disassembly to Build Activatable Trimodal Probe for Molecular Imaging of Biothiols, ACS Nano, 2016, 10(11):10075-10085.

Luyan Wu (吴鲁艳), B.S.

  Education:

  Sep 2017–Present: Ph. D. Candidate in Analytical Chemistry,

               Shool of chemistry and chemical engineering,

               Nanjing University

  Sep 2013–Jul 2016: M.S. in Chemistry,

                Shool of chemical and materials engineering,

                Jiangnan University

               Supervisors: Prof. Caihua Ni

  Sep 2009–Jul 2013:  B.S. in Bioengineering, Yantai University.

  Email: wuluyan0027@163.com

  Tel: 025-89681916

  Rm A-526, Chemical Building

 

My personal profile: I like chemistry. I like facing challenges in experiment.

I am developing probes for small biomolecules detection.

 

Publications:

1.L. Y. Wu, C. H. Ni et al., Surface Charge Convertible and Biodegradable Synthetic Zwitterionic Nanoparticles for Enhancing Cellular Drug Uptake. Macromolecular Bioscience. 2016, 16, 308– 313.

2.L. Y. Wu, L. P. Zhang, G. Shi, C. H. Ni, Zwitterionic pH/redox nanoparticles based on dextran as drug carriers for enhancing tumor intercellular uptake of doxorubicin[J]. Materials Science and Engineering C. 2016, 61,278 –285.

3. L. Y. Wu, C. H. Ni et al.,Preparation of pH sensitive zwitterionic nano micelles and drug controlled release for enhancing cellular uptake. Journal of Biomaterials Science, Polymer Edition. 2016, 27, 643-656.

 

Yuqi Wang (王宇琦), M.S.

  Education:

  Sep 2014–Present:  Ph.D Candidate, School of Chemistry and Chemical Engineering,

                 Nanjing University.

                 Supervisors: Prof. Yan Zhang                                                                  

  Sep 2008–Jul 2012:  B.S. in Chemistry, College of Chemistry and Materials Science,

                 Northwest University.

  Email: 18551836184@163.com

  Tel: 025-89681915

  Ad: Rm A-523, Chemical Building

 

 

 

 

My personal profile: Learn from yesterday, live for today, hope for tomorrow.

I am developing probes for multimodality imaging of enzyme activity in living cells and in live animals.

 

Publications:

1. Y. Wang, J. Li, L. Feng, J. Yu, Y. Zhang, D. Ye and H. Chen. A lysosome-targeting fluorogenic probe for cathepsin B imaging in living cells. Anal. Chem., 2016, 88 (24), 12403–12410

2. M. Zheng, Y. Wang, H. Shi, Y. Hu, L. Feng, Z. Luo, M. Zhou, J. He, Y. Zhou, Y. Zhang and D. Ye. Redox-mediated disassembly to build activatable trimodal probe for molecular imaging of biothiols. ACS Nano. 2016, 10 (11), 10075–10085

3. K. Yang, Y. Wang, X. Chen, A. A. Kadi, H. K. Fun, H. Sun, Y. Zhang and H. Lu. Nickel-catalyzed and benzoic acid-promoted direct sulfenylation of unactivated arenes. Chem. Commun., 2015, 51, 3582-3585

4. K. Yang, X. Chen, Y. Wang, W. Li, A. A. Kadi, H. K. Fun, H. Sun, Y. Zhang, G. Li, and H. Lu. Cobalt-catalyzed decarboxylative 2‑benzoylation of oxazoles and thiazoles with α‑oxocarboxylic acids J. Org. Chem., 2015, 80, 11065-11072

Runqi Yan (颜润琦), B.S.

  Education:

  Sep 2016–Present: M.S. Candidate in school of chemistry and chemical engineering,

               Nanjing University.

  Sep 2016–Jul 2012: B.S. in College of Chemistry,

                Chemical Engineering and Materials Science,

                Soochow University.

  Email: runqiyan@163.com

  Tel: 025-89681915

  Ad: Rm A-523, Chemical Building

 

 

 

 

My personal profile: Strive to make every day joyful and meaningful,not for others,but for myself.

I am developing probes for imaging of GGT enzyme activity in living cells and in live animals.

 

Publications:

Yan R, Ye D. Molecular imaging of enzyme activity in vivo using activatable probes[J]. Science Bulletin, 2016, 61(21):1672-1679.

 

Tieying Xue (薛铁瑛),

  Education:

  Sep 2017–Present:  M.S. Student in Analytical Chemistry,

                School of Chemistry and Chemical Engineering,

                Nanjing University.

  Sep 2013–Jul 2017:  B.S.in Chemistry, School of Nanjing Normal University.

                 Research Advisor: Prof.Yawen Tang

  Email: xuetieying@163.com

  Tel: 025-89681916

  Ad: Rm A-526, Chemical Building

 

 

 

I like analytical chemistry, which can improve my logical thinking. I believe chemical can make my dream come true and make my life better.

My personal profile: Try my best to make myself better.

 

Publications:

PtCu nanodendrite-assisted synthesis of PdPtCu concave nanooctahedra for efficient electrocatalytic methanol oxidation. Catalysis Science & Technology, 2015,5:5105-5109. Ming-Xing Gong,Xian Jiang,Tie-Ying Xue,Tian-Yi Shen,Lin Xu,*Dong-Mei Sun and Ya-wen Tang*

Zheng Huang (黄郑),

   Education:

   Sep 2015-Present: Undergraduate student, School of Chemistry and Chemical Engineering,

                Nanjing University.

   Email: 704753279@qq.com

   

   My personal profile:

   I like organic chemistry, especially to discover and synthesize potential drug molecule.

   I more like communicating with my upperclassman and professor to improve myself.

   I have got second prize in the 27th national high school chemistry Olympic.

 

 

Zhiliang Luo (罗治亮), M.S.

  Education:

  Sep 2015–Jun 2018: M.S. in Chemistry,

               School of Chemistry and Chemical Engineering,

               Nanjing University.

  Sep 2011–Jul 2015: B.S. in Applied Chemistry,

               School of Chemistry, Chemical Engineering and Life Science,

               Wuhan University of Technology.

  Email: lzl940528@163.com

  TEL: 025-89681915

  Ad: Rm A-523 Chemical Building

 

My personal profile: I like analytical chemistry, especially like to build fluorescent probes to light up biomolecules.

In leisure time, I’d like to talk with my friends and do some reading.

I am developing near-infrared fluorescence probes for non-invasive imaging of enzyme activity in living cells and in live animals.

Liandong Feng (丰连东), Ph.D.

  Education:

  Sep 2015–Present:   Postdoctoral Fellow in drug delivery and molecular imaging,

                  Nanjing University.

  Sep 2007–Jul 2014:  Ph.D. and M.S. in drug delivery and gene delivery,

                 Nanjing University of Science and Technology.

                 Supervisors: Prof. Wei Dong

  Sep 2003–Jul 2007:  B.S. in Chemical engineering and technology,

                 School of Chemistry and Chemical Engineering,

                 Nanyang Institute of Technology.

  Email: fengliand@126.com

  TEL: 025-89681915

  Ad: Rm A-523, Chemical Building

 

My personal profile: I like to build stimulus-responsive nanoparticles that selectively target to tumor.

I more like to enjoy my leisure time with my wife.

 

I am developing nanoparticles for drug delivery and multimodality imaging of bioactive molecule in living cells and in live animals.

 

 

Yizhong Sen ( 沈益忠), Ph.D.

  Dr. Shen is now working as an associated professor in Hefei University of Technology.

  Education:

  Sep 2014–Nov 2017:  Ph.D. , School of Chemistry and Chemical Engineering,

                Nanjing University.

                Supervisors: Prof. Hong-Yuan Chen

  Sep 2011–Jul 2014:  M.S. in Chemistry, School of Chemistry and Chemical Engineering,

               Southwest University.

               Supervisors: Prof. Shaopu Liu and Prof. Youqiu He

  Email:hmsyz1987@126.com

  Tel: 025-89681915

  Ad: Rm A-523, Chemical Building

 

 

I am developing nanoprobes for sensing, imaging and therapy in living cells and in live animals.

Publications:

1.Yizhong Shen, Adam J. Shuhendler, Deju Ye*, Jing-Juan Xu, Hong-Yuan Chen*. Two-photon excitation nanoparticles for photodynamic therapy. Chem. Soc. Rev. 2016, 45, 6725-6741.

2.Qiu-Mei Feng+, Yizhong Shen+, Mei-Xing Li+, Zhuo-Lei Zhang, Wei Zhao*, Jing-Juan Xu*, Hong-Yuan Chen. Dual-wavelength electrochemiluminescence ratiometry based on resonance energy transfer between Au nanoparticles functionalized g‑C3N4 nanosheet and Ru(bpy)32+ for microRNA detection. Anal. Chem., 2016, 88, 937−944. (+ Equal contributions)

 

 

Yingxiao Yan (闫英笑),

  

  Education:

 

  Sep 2015-Present: Undergraduate of the Department of Chemistry,

              Nanjing University

  Email: 1335769612@qq.com

   

  My personal profile:

  I like chemistry combined with biology. I am obsessed with how chemistry plays its role in biological activity in cells.

  I also like  literature and art, which bring peace to my heart.

  I am studying in the Department of Chemistry in Nanjing University and I am in the research group of Professor Ye to learn more and to get   more experimental training.