Own group aims to construct molecular structure and discover their reactivity that can contribute to  interdisciplinary solutions for the important challenges in science. We has a fundamental interest in developing innovative synthetic strategies for potential applications. Particularly, we focus on efficient & green synthetic methodology development, complex molecule synthesis, and mechanistic studies to develop practical access to molecules of interest in catalysis, medicine, and organic materials. Currently, we are interested in developing synergistic catalysis effect in organic synthesis. It represents a rationally design innovative catalytic solutions to improve our access to molecular sciences.


Visible-light Photoredox Catalysis/Heteroatom Radical Synergistic Chemitry

     We have achieved visible-light photoredox catalysis/thiyl radical combination for C-H and B-H bond activation (Angew. Chem. Int. Ed. 2018, 57, 3990-3994; Angew. Chem. Int. Ed. 2018, 57, 10357-10361). Also, an unprecedented visible-light photoredox catalysis/ phosphoranyl radical chemistry has been developed, which allows for mild C-O bond activation of carboxylic acids (Nature Commun. 2018, 9, 3517; Angew. Chem. Int. Ed. 2019, 58, 312-316). Most importantly, this new catalytic combination can break through the existing redox-potential limitation of substrates in photoredox catalysis. Once the optimized conditions was established, it can be applied in different coupling partners with a very broad scope as well as the late-stage functionalization of complex molecules.

Representative publications:  a) Nature Commun. 2018, 9, 3517; b) Angew. Chem. Int. Ed. 2019, 58, 312-316; c) Angew. Chem. Int. Ed. 2018, 57, 3990-3994; d) Angew. Chem. Int. Ed. 2018, 57, 10357-10361.


Dimeric Bimetallic Catalysis

     In recent years, transition metal-catalyzed new chemical bond forming has gained great momentum in synthetic chemistry as it offers a new window to exploit unexplored chemical space. Among the transition metal-catalyzed organic transformations, they are currently dominated by mononuclear metal catalyst precursors. Indeed, in nature most metalloenzymes contain binuclear or multinuclear metal centers. For example, the urease from Bacillus pasteurii contains dinuclear Ni which is bridged by β-mercaptoethanol in the active site through the sulfur atom and chelates one Ni through hydroxyl group. The synergistic interaction between two or more metals enables metalloenzymes with high efficiency, robustness and exclusive selectivity. Inspired by this interesting nature evolution, we focus on invetigating the catalytic reactivity of dimeric metal catalyst precusors, with a particular interest in dimeric manganese and gold catalysis. An interdisciplinary approach drawing from the areas of organic synthesis, organometallic chemistry, supramolecular chemistry, medicinal chemistry and inorganic chemistry will be used to rationally conduct this research.

Representative publications: a) Angew. Chem. Int. Ed. 2018, 57, 12906-12910;  b) Angew. Chem. Int. Ed.  2018, 57, 16648-16653; c) Synlett, DOI:10.1055/s-0037-1610335



©2017 Nanjing University Xie Group